Abstract: To achieve good indoor living environment,improve the quality of staff living environment in refuge chambers and provide a basis guidance of design for the future,based on numerical simulation software FLUENT,the survival area under the way of air pressure supply was used as a research object,the main disturbance source was analyzed,and a three-dimensional model was set up with two kinds of air pressure supply pipelines. Air distribution in refuge chambers was visualized through the control equations,the RNG k-ε turbulence model and the finite volume discrete method in combination with SIMPLE algorithm. In the condition of air pressure supply,the layout of a uniform gas pipeline with nine air holes was determined as the optimal design scheme,and the volume fraction distribution regularities of oxygen and carbon dioxide were obtained. The feasibility of this numerical simulation was verified with field test.