Abstract: The emission of nitrogen oxides (NO_x), the primary air pollutant in China, reached 8.96 million tons in 2022, considerably higher than the emissions of volatile organic compounds, particulate matter, and sulfur dioxide (SO₂). NO_x emission control is the focus and challenge with respect to air pollution management in China. Selective catalytic reduction (SCR) is widely employed to control the emission of NO_x in industrial flue gas because of its high efficiency and stability, and it can be used to realize ultralow NO_x emission. A catalyst is a vital factor of the SCR technology. Commercial V₂O₅/TiO₂ catalysts have satisfactory tolerance to poisoning factors such as SO₂ and H₂O, and the operating temperature is generally in the high-temperature range of 300–420 ℃. Although the catalysts can be more effectively adapted to the medium-temperature range of 200–300 ℃ by increasing the loading amount of V₂O₅, their low-temperature activity is poor at temperatures less than 200 ℃. The development of efficient and stable catalysts for SCR at low temperatures can prevent the high energy consumption associated with flue gas reheating, resulting in considerable energy saving and carbon reduction benefits. Manganese oxides (MnO_x) exhibit remarkable redox properties due to variable chemical states and abundant lattice defects, and they have considerably strong surface acidity, showing satisfactory low-temperature activity in the reaction of catalytic reduction of NO_x. However, Mn-based catalysts suffer poor resistance to H₂O/SO₂, making it difficult to achieve efficient and stable denitrification (i.e., deNO_x) over an extended period of time. They have poor N₂ selectivity and are prone to catalytic conversion of NO_x into the greenhouse gas N₂O. Modification and enhancement of Mn-based catalysts have been extensively researched in recent years, which has expedited the pace of their industrial application. This study summarizes the latest research progress on reaction mechanism, elemental doping, and structure design of Mn-based catalysts in the aspects of low-temperature activity, N₂ selectivity, and stability. Elemental doping modification is the primary method for optimizing the N₂ selectivity and H₂O/SO₂ tolerance of these catalysts. In terms of comprehensive low-temperature activity, N₂ selectivity, and stability, the doping components should have satisfactory oxygen storage–release ability to provide abundant oxygen vacancies and high stability to disperse MnO_x and increase the tolerance to H₂O and SO₂; appropriate structural design can block the poisoning of H₂O and SO₂; in particular, surface hydrophobic modification can weaken the promotion effect of H₂O on poisoning of SO₂. In conclusion, this study indicates the ongoing research focuses and difficulties, which can provide references for future research.