Abstract: Based on platforms including VC#. net, SQL Server 2008 and geographic information systems (GIS), the mine map was developed with geographical attributes. A rescue system based on refuge chambers during the mine fire period was constructed after the graphics library, database, method library and knowledge base were established. Due to real time simulation of mine fire, analysis and prediction of its dynamic trend, the rescue system achieved a dynamic visual display of fire plume spreading and the optimal escape route based on refuge chambers in an underground coal mine. At the same time, roadway safety and traffic efficiency were introduced to amend the traffic capacity of post-disaster roadways. The principles for selecting the optimal rescue route based on refuge chambers were determined, and the "ideal-viable-escape" level of escape routes was divided. Since the optimal escape route was calculated using Dijkstra algorithm which was improved by the stack data structure, the computing speed of the rescue system online increased. The rescue system has been applied to Changcun Coal Mine owed to Lu'an Group.