Abstract: Based on the material balance principle, a functional relation of the total vanadium content of tailings with the total vanadium content of calcination-clinker, calcination conversion rate and leaching rate was established, and the validity of the equation was proved with industrial production data. The effects of interactions between independent variables in the equation on the total vanadium content of railings were systematically studied; as a result, the original equation was further simplified. The results show that the internal relation of the total vanadium content of tailings to the above-mentioned factors can be accurately reflected through the original equation and the reduced equation, which can provide a basis of judgment for technical control of the total vanadium content of tailings in actual production. On the other hand, the reduced equation is so simple that it is more favorable to practical applications.