Abstract: The Al_xTiVCrMnFeCoNiCu high-entropy alloys, designed by using the strategy of high entropy of mixing, were investigated on room-temperature mechanical properties. The four alloys have the compressive strength higher than 1.3 GPa and the compressive strength of AlTiVCrMnFeCoNiCu alloy reaches 2.4 GPa. Besides, both AlTiVCrMnFeCoNiCu and Al₂TiVCrMnFeCoNiCu alloys exhibit compressive plasticity. For the alloy system, the microhardness in both dendrite and interden-drite area increase with increasing Al content. Such excellent room-temperature mechanical properties should be attributed to the solution strengthening, the dispersion strengthening of nano-scale particles, and the structure transformation from ductile face-centered cubic phases to strong body-centered cubic phases.