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能反映塵肺病理的肺磁場弛豫參量

The Lung's Magnetic Relaxation Parameter Being Able to Tracing the Pneumoconiosis Pathology

  • 摘要: 在改進弛豫曲線擬合方程為雙對數模型的基礎上,提出一個能綜合反映肺磁場弛豫特性的新參量α*。通過對一批大劑量染鐵硅混合塵的大鼠病理模型進行實驗,得到了α*隨染塵后時間τ的變化規律,發現α*隨動物臨床死亡后的時間以雙曲線規律下降,弛豫α*值與動物病理切片的評分值呈線性相關。

     

    Abstract: Based on proposing a new equation B=Bo + BI In (t+1) +B11 1n2 (t + 1) for fitting the relaxation curve, a new relaxation parameter, which can characterize the curve comprehensively, is put forword. Byexperimentally investigating a number of rats exposed to 80 mg SiO2+20mg Fe3O4 particles, the variation law; of α* vs. the time after exposure &/or death are gained. A highly significant linear negative correlation between the α* values and the grade data got from the pathologic sections is discovered.

     

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